Pineapple, a juicy and tasty fruit, belonging to family Bromeliaceae is scientifically known as Ananas comosus. The Pineapples are traditionally used as a blood purifier, to aid digestion, for gastrointestinal disorders, diseases of the larynx and pharynx, as a mild antiseptic and to treat diabetes. There are no reports in literature pertaining to CNS actions of Ananas comosus fruit. In the light of above, the present study was undertaken to test the antidepressant potential of Ananas comosus fruit juice. Ananas comosus juice (ACJ) was administered at various concentrations ranging from 5% to 20% v/v to Swiss albino mice for 15 days and wistar rats for 8 successive days. The antidepressant activity was measured using forced swim test (FST), tail suspension test (TST) and reserpine induced hypothermia. The efficacy of Pineapple juice was compared with standard anti-depressant agents viz: fluoxetine (20 mg/kg) and imipramine (15 mg/kg). The results showed that Pineapple juice significantly decreased immobility time in both FST and TST models. It also reversed the hypothermia induced by reserpine. The efficacy of Pineapple juice was found to be comparable to fluoxetine and imipramine. Prazosin, sulpiride, baclofen and p-CPA antagonized the antidepressant effect of Pineapple juice in tail suspension test. Furthermore, Ananas comosus juice inhibited the monoamine oxidase MAO-A and MAO-B activity and reduced significantly malondialdehyde (MDA) levels. These findings reveal the antidepressant potential of Pineapple. 

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